Highly Diastereoselective Synthesis of Polysubstituted Cyclopropanecarbonitriles via Palladium-Catalyzed Cyanoesterification of Cyclopropenes

Can Li, Rongrong Yu, Song-Zhou Cai and Xianjie Fang*

*College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, 2318 Yuhangtang Road, Hangzhou 311121, China, Email: fangxjhznu.edu.cn

C. Li, R. Yu, S.-Z. Cai, X. Fang, Org. Lett., 2023, 25, 5128-5133.

DOI: 10.1021/acs.orglett.3c01875

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Abstract

A palladium-catalyzed direct cyanoesterification of cyclopropenes enables a highly atom economic and diastereoselective synthesis of synthetically useful cyclopropanecarbonitriles. The reaction offers mild conditions, good functional group compatibility, and simple operation.

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Key Words

cyanation, carboxylation, cyclopropanes

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ID: J54-Y2023