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Metal-Free Construction of Multisubstituted Indolizines via Intramolecular Amination of Allylic Alcohols

Xinxin Lv, Penghui Gao, Xiaowei Zhao and Zhiyong Jiang*

*College of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453000, People's Republic of China, Email:

X. Lv, P. Gao, X. Zhao, Z. Jiang, J. Org. Chem., 2023, 88, 9459-9468.

DOI: 10.1021/acs.joc.3c00469

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An intramolecular amination of allylic alcohols provides an efficient, general, and metal-free access to biologically important multisubstituted indolizines in high yields either using aqueous hydrochloric acid solution or p-toluenesulfonic acid as the catalyst.

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proposed mechanism

Key Words


ID: J42-Y2023