CuII-Catalyzed cis-Selective Synthesis of Ketoepoxides from Phenacyl Bromides and Water
Debasish Ghosh, Sabir A. Molla, Narendra Nath Ghosh, Saikat Khamarui* and Dilip K. Maiti*
*Government General Degree College, Kalna-1, Burdwan 713405; University of Calcutta, 92, A. P. C. Road, Kolkata 700009, India,
Email: saikatkhamarui21
gmail.com, dkmchemcaluniv.ac.in
D. Ghosh, S. A. Molla, N. N. Ghosh, S. Khamarui, D. K. Maiti, J. Org. Chem., 2023, 88, 9657-9667.
DOI: 10.1021/acs.joc.2c02835
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Abstract
A CuII-catalyzed oxidative C-C/O-C homocoupling/cyclization strategy of phenacyl bromides provides α,β-ketoepoxides with high yield and cis-selectivity. The homocoupling method was extended to cross-coupling between phenacyl bromides with benzyl bromides.
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proposed mechanism for homocoupling
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Key Words
ID: J42-Y2023
