Regio- and Enantioselective Catalytic δ-C-H Amidation of Dioxazolones Enabled by Open-Shell Copper-Nitrenoid Transfer
Suhyeon Kim, Se Lin Song, Jianbo Zhang, Dongwook Kim, Sungwoo Hong and Sukbok Chang*
*Department of Chemistry, Korea Advanced Institute of Science
and Technology (KAIST), Daejeon 34141, South Korea, Email: sbchang
kaist.ac.kr
S. Kim, S. L. Song, J. Zhang, D. Kim, S. Hong, S. Chang, J. Am. Chem. Soc., 2023, 145, 16238-16248.
DOI: 10.1021/jacs.3c05258
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Abstract
An asymmetric δ-C(sp3)-H amidation of dioxazolones using a Cu(I) precursor with a chiral bisoxazoline ligand as catalyst provides six-membered lactams with high to excellent regio- and enantioselectivity.
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proposed mechanism
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Key Words
ID: J48-Y2023
