Palladium-Catalyzed Regioselective Intermolecular Hydroalkoxylation of 1-Arylbutadienes
Rodney A. Fernandes*, Naveen Chandra, Ashvin J. Gangani, and Gulenur N. Khatun
*Department of Chemistry, Indian Institute of Technology
Bombay, Powai, Mumbai, Maharashtra 400076, India, Email: rfernand
chem.iitb.ac.in
R. A. Fernandes, N. Chandra, A. J. Gangani, G. N. Khatun, J. Org. Chem., 2023, 88, 10139-10354.
DOI: 10.1021/acs.joc.2c01252
see article for more reactions
Abstract
An efficient Pd-catalyzed regioselective intermolecular hydroalkoxylation of 1-arylbutadienes provides (E)-(3-alkoxybut-1-enyl)benzenes. This convenient method requires no dry reaction conditions and tolerates a wide range of substrates. Chloromethyl methyl ether (MOMCl) as an additive was found to be essential for the success of the reaction.
see article for more examples
proposed mechanism
Key Words
ID: J42-Y2023
