Synthesis of Triarylphosphines via Cu-Catalyzed Coupling of Aryl Halides and Acylphosphines

Minghui Xu , Zhengping Zhu , Haojie Yi , Hong Zhu*, Zhiqian Wang*

*Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. of China, Email: zhuho128126.com, wangzhqmail.buct.edu.cn

M. Xu, Z. Zhu, H. Yi, H. Zhu, Z. Wang, Synthesis, 2023, 55, 2586-2594.

DOI: 10.1055/a-2067-4165

---

see article for more reactions

Abstract

CuCl₂ catalyzes a C(sp²)-P bond forming reaction of aryl iodides and bromides with an acylphosphine as the phosphorus source to provide triarylphosphines in very good yield. A preliminary study of the mechanism was carried out and found that a radical intermediate is not involved.

see article for more examples

---

---

Key Words

Cu catalysis, acylphosphines, C(sp₂)-P bond formation, triarylphosphines, phosphines, phosphination reagent

---

ID: J66-Y2023