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Dehydroxylative Cyanation of Alcohols Promoted by Triphenyphosphine/1,2-Diiodoethane

Ling Luo, Jin-Hong Lin*, Ji-Chang Xiao*

*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, P. R. of China, Email: jlinsioc.ac.cn, jchxiaosioc.ac.cn

L. Luo, J.-H. Lin, J.-C. Xiao, Y. Hu, Synthesis, 2023, 55, 1593-1596.

DOI: 10.1055/a-2029-0694



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Abstract

A Ph3P/ICH2CH2I-promoted dehydroxylative cyanation of alcohols avoids the use of transition metals or moisture-sensitive Lewis acids. This protocol features convenient operations, mild reaction conditions, and the use of cheap and widely available reagents.


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Key Words

dehydroxylation, alcohols, cyanation, hydroxyl group, nucleophilic substitution


ID: J66-Y2023