Pd-Catalyzed Multicomponent Cross-Coupling of Allyl Esters with Alkyl Bromides and Potassium Metabisulfite: Access to Allylic Sulfones

Kai-Yi Zhang, Fang Long, Chuan-Chong Peng, Jin-Hui Liu and Li-Jun Wu*

*College of Sciences, Central South University of Forestry and Technology, Changsha 410004, China, Email: t20202522csuft.edu.cn

K.-Y. Zhang, F. Long, C.-C. Peng, J.-H. Liu, L.-J. Wu, Org. Lett., 2023, 25, 5817-5821.

DOI: 10.1021/acs.orglett.3c02066

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Abstract

A Pd-catalyzed multicomponent cross-coupling of allyl esters with alkyl bromides and K₂S₂O₅ provides allylic sulfones with high linear and exclusive E selectivity. The reaction displays an excellent functional group compatibility.

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proposed mechanism

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Key Words

allylic sulfones, alkyl sulfones, multicomponent reactions

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ID: J54-Y2023