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N-Heterocyclic Nitrenium-Catalyzed Photohomolysis of CF3SO2Cl for Alkene Trifluoromethylation

Xiao-Jian Ren, Peng-Wei Liao, He Sheng, Zhi-Xiang Wang* and Xiang-Yu Chen*

*School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China, Email:,

X.-J. Ren, P.-W. Liao, H. Sheng, Z.-X. Wang, X.-Y. Chen, Org. Lett., 2023, 25, 6189-6194.

DOI: 10.1021/acs.orglett.3c02380

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N-Heterocyclic nitreniums (NHNs) catalyze a photohomolysis of CF3SO2Cl resulting in the CF3 radical for trifluormethylation of alkenes. This method is operationally simple and without using transition metals and oxidants.

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proposed mechanism

Key Words


ID: J54-Y2023