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Green Chemistry Approach toward the Regioselective Synthesis of α,α-Disubstituted Allylic Amines

Shahid Khan, Muhammad Salman, Yu Wang, Junjie Zhang and Ajmal Khan*

*Department of Chemistry, School of Chemistry, Xi'an Jiao Tong University, Xi'an 710049, P. R. China, Email: ajmalkhanxjtu.edu.cn

S. Khan, M. Salman, Y. Wang, J. Zhang, A. Khan, J. Org. Chem., 2023, 88, 11992-11999.

DOI: 10.1021/acs.joc.3c01320


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Abstract

A robust and convenient molybdenum-catalyzed regioselective allylic amination of tertiary allylic carbonates provides α,α-disubstituted allylic amines in high yield with complete regioselectivity in ethanol as green solvent. Both aromatic and aliphatic amines react with various tertiary allylic alcohol derivatives. The catalyst can be recycled through simple centrifugation techniques.

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Key Words

allylic amines, green chemistry


ID: J42-Y2023