Decarboxylative N-Formylation of Amines with Glyoxylic Acid Promoted by H₂O₂

Jiwei Wu, Yuting Zhang, Jingyi Yang, Lingxiang Yu, Shaoqing Zhang, Jie Zhou, Zirong Li*, Xiaolan Xu* and Huajian Xu*

*Hefei University of Technology, Hefei, 230009; Anhui Medical University, Hefei, 230009, P. R. China, Email: lizirahstu.edu.cn, xlxuustc.edu.cn, hjxuhfut.edu.cn

J. Wu, Y. Zhang, J. Yang, L. Yu, S. Zhang, J. Zhou, Z. Li, X. Xu, H. Xu, J. Org. Chem., 2023, 88, 13590-13597.

DOI: 10.1021/acs.joc.3c01270

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Abstract

An efficient decarboxylative N-formylation of amines with glyoxylic acid provides formamides in good yields. The reaction tolerates a wide range of functional groups under metal free and base free conditions. In addition, large-scale experiments and high chemoselectivity have shown great potential application of this strategy.

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proposed mechanism

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Key Words

amides, hydrogen peroxide

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ID: J42-Y2023