Visible-Light-Induced Synthesis of 3-Alkyl Chromones under Catalyst- and Additive-Free Conditions
Wei Zhao, Zhiqin He, Xiaohui Yang, Yang Yu, Jonathan B. Baell* and Fei Huang*
*School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, P. R. China,
Email: jonathan.baell
njtech.edu.cn, huangfei0208yeah.net
W. Zhao, Z. He, X. Yang, Y. Yu, J. B. Baell, F. Huang, J. Org. Chem., 2023, 88, 13634-13644.
DOI: 10.1021/acs.joc.3c01339
Abstract
Visible light induces an efficient and facile 3-alkyl chromone synthesis from easily accessible o-hydroxyaryl enaminones and α-diazo esters under mild conditions. This additive-free method provides excellent yields with a broad substrate scope at room temperature, tolerating various functional groups.
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Key Words
Chromones, Photochemistry
ID: J42-Y2023
