Synthesis of Polysubstituted Furans via Rh(II)-Catalyzed [2 + 3] Annulation of N-Sulfonyl-1,2,3-triazoles with Enaminones

Xiaoqiang Lei*, Juan Feng, Qinglan Guo, Yuanhe Li* and Jiangong Shi*

*Peking Union Medical College, Beijing 100050; Peking University, Beijing 100871, China, Email: xqleiimm.ac.cn, liyuanhepku.edu.cn, shijgimm.ac.cn

X. Lei, J. Feng, Q. Guo, Y. Li, J. Shi, Org. Lett., 2023, 25, 7338-7343.

DOI: 10.1021/acs.orglett.3c02771

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Abstract

The cooperative catalysis of Rh(II) and a Brønsted acid enables an unprecedented [2 + 3] annulation of N-sulfonyl-1,2,3-triazoles with enaminones to provide polysubstituted furans.

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proposed mechanism

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Key Words

furans

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ID: J54-Y2023