Catalyst-Free, Multicomponent Reaction of Iodonium Ylides, Nitrosoarenes, and Olefins for the Synthesis of Isoxazolidine Derivatives
Yan-Rui Zhao, Lei Li*, Jun Xuan*
*Liaocheng University, Liaocheng 252000; Anhui University, Hefei, Anhui 230601, P. R. of China,
Email: llee2005
163.com, xuanjunahu.edu.cn
Y.-R. Zhao, L. Li, J. Xuan, Synlett, 2023, 34, 2022-2028.
DOI: 10.1055/a-2107-5567
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Abstract
A three-component reaction of nitrosoarenes, olefins, as well as iodonium ylides provides N-aryl isoxazolidines derivatives in good yields. This reaction includes a 1,3-dipolar cycloaddition of nitrones generated in situ from iodonium ylides and nitroso compounds, with olefins in the absence of any catalysts and additives.
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Key Words
iodonium ylides, nitrosoarenes, olefins, isoxazolidines, catalyst free, multicomponent reactions
ID: J72-Y2023
