Benzannulation with Et₃N as 1,3-Diene Variants

Lipeng Long, Wenjia Wang, Yuping Zhu, Wenjun Luo, Yi Zhang, Juxiu Chen, Yuting Wei and Zhengwang Chen*

*Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, PR China, Email: chenzwang2021163.com

L. Long, W. Wang, Y. Zhu, W. Luo, Y. Zhang, J. Chen, Y. Wei, Z. Chen, Org. Lett., 2023, 25, 7775-7779.

DOI: 10.1021/acs.orglett.3c02620

---

see article for more reactions

Abstract

A simple and practical benzannulation of maleimides with triethylamine as a 1,3-diene synthon provides phthalimides in good yields under mild conditions. The transformation can be performed in the absence of a metal catalyst with high levels of functional group tolerance.

see article for more examples

proposed mechanism

---

---

Key Words

phthalimides, dibenzoyl peroxide, oxygen

---

ID: J54-Y2023