Palladium-Catalyzed Enantioselective Hydrohydrazonation of 1,3-Dienes
Shaozi Sun, Qinglong Zhang, Weiwei Zi*
*State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China, Email: zinankai.edu.cn
S. Sun, Q. Zhang, W. Zi, Org. Lett., 2023, 25, 8397-8401.
DOI: 10.1021/acs.orglett.3c03519
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Abstract
(R)-DTBM-Segphos-Pd(0) catalyzes a hydrohydrazonation of 1,4-disubstituted 1,3-dienes to provide allylic chiral hydrazones in good yields with good regio- and enantioselectivity. This transformation tolerates a wide range of substrates and functional groups.
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proposed mechanism
Key Words
ID: J54-Y2023