Iridium-Catalyzed 1,3-Rearrangement of Allylic Ethers
Fei Li, Jinbao Ren, Yifan Song, Qianjia Yuan*, Deyue Yan, Wanbin Zhang*
*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China,
Email: yuanqianjiasjtu.edu.cn, wanbin
sjtu.edu.cn
F. Li, J. Ren, Y. Song, Q. Yuan, D. Yan, W. Zhang, Org. Lett., 2023, 25, 8727-8732.
DOI: 10.1021/acs.orglett.3c03661
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Abstract
An iridium-catalyzed 1,3-rearrangement of readily available allylic ethers provides allylic ethers with a large steric hindrance. The developed method shows a broad substrate scope and could be used in the late-stage modification of several natural products.
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proposed mechanism
Key Words
ID: J54-Y2023