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Iridium-Catalyzed 1,3-Rearrangement of Allylic Ethers

Fei Li, Jinbao Ren, Yifan Song, Qianjia Yuan*, Deyue Yan, Wanbin Zhang*

*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China, Email: yuanqianjiasjtu.edu.cn, wanbinsjtu.edu.cn

F. Li, J. Ren, Y. Song, Q. Yuan, D. Yan, W. Zhang, Org. Lett., 2023, 25, 8727-8732.

DOI: 10.1021/acs.orglett.3c03661


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Abstract

An iridium-catalyzed 1,3-rearrangement of readily available allylic ethers provides allylic ethers with a large steric hindrance. The developed method shows a broad substrate scope and could be used in the late-stage modification of several natural products.

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proposed mechanism



Key Words

ethers, isomerization


ID: J54-Y2023