Desymmetrization and Parallel Kinetic Resolution of 1-Ethynylcyclobutanols via Asymmetric Cooperative Gold Catalysis
Ke Zhao, Ziguang Yang, Jielin Yang, Xinyi Li, Carlos D. Quintanilla, Liming Zhang*
*Department of Chemistry and Biochemistry, University of
California, Santa Barbara, California 93117, United States, Email: zhang
chem.ucsb.edu
K. Zhao, Z. Yang, J. Yang, X. Li, C. D. Quintanilla, L. Zhang, J. Am. Chem. Soc., 2023, 145, 27205-27210.
DOI: 10.1021/jacs.3c09288
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Abstract
Gold-ligand cooperation in the presence of a chiral bifunctional phosphine ligand featuring a 3'-phosphine oxide moiety enables a highly enantioselective desymmetrization of 1-ethynylcyclobutanols to provide chiral α-methylenecyclopentanones featuring a diverse array of chiral quaternary and tertiary centers.
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Key Words
ID: J48-Y2023
