Oxidative Cyclization Reactions Catalyzed by Designed Transition-Metal Complexes: A New Strategy for the Synthesis of Flavone, Quinolone, and Benzofuran Derivatives
Apurva Singh, Sain Singh, Kaushik Ghosh*, Naseem Ahmed*
*Department of Chemistry, Indian Institute of Technology
Roorkee, Uttarakhand 247667, India, Email: naseem.ahmedcy.iitr.ac.in,
kaushik.ghosh
cy.iitr.ac.in
A. Singh, S. Singh, K. Ghosh, N. Ahmed, Synthesis, 2023, 55, 4191-4203.
DOI: 10.1055/s-0042-1751489
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Abstract
The use of transition-metal catalysts and TEMPO enables an efficient synthesis of 2-phenyl-4H-chromen-4-one, 2-phenylquinolin-4(1H)-one, and 11H-benzofuro[3,2-b]chromen-11-one derivatives in good yields from 2'-hydroxychalcones, 2'-aminochalcones, and 3-hydroxyflavones, respectively. The methods offer high atom-economy, use of benign solvent and auxiliaries, and easy handling.
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Key Words
flavones, 4-quinolones, oxidative cyclization, heterocyclization, TEMPO, oxygen
ID: J66-Y2023