2,2'-Biphenol-Derived Phosphoric Acid Catalyst for the Dehydrative Esterification of Carboxylic Acids with Alcohols
Manabu Hatano*, Chiaki Nishioka, Ayaka Mimura, Risa Kimura, Yuki Okuda, Takeshi Yamada, Ken Sakata*
*Kobe Pharmaceutical University, Higashinada, Kobe 658-8558;
Toho University, Funabashi, Chiba 274-8510, Japan, Email: mhatano
kobepharma-u.ac.jp,
ken.sakataphar.toho-u.ac.jp
M. Hatano, C. Nishioka, A. Mimura, R. Kimura, Y. Okuda, T. Yamada, K. Sakata, Synlett, 2023, 34, 2508-2514.
DOI: 10.1055/s-0042-1752738
see article for more reactions
Abstract
A simple 2,2'-biphenol-derived phosphoric acid catalyst promotes a dehydrative esterification from an equimolar mixture of carboxylic acids and primary or secondary alcohols in toluene at 100 °C without the necessity to remove water. This reaction was also successfully conducted at the gram scale.
see article for more examples
Key Words
alcohols, carboxylic acids, esters, benzyl esters, DFT calculations, esterification, green chemistry, organocatalysis, phosphoric acid
ID: J72-Y2023
