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Rapid and General Access to α-Haloketones Using Quaternary Ammonium Salts as Halogen Sources

Nan Wu*, Mengfei Jiang, Ashley Cao, Lei Huang, Xiumei Bo, Zhou Xu*

*School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China, Email: 100002018070xzhmu.edu.cn, xuzhouxzhmu.edu.cn

N. Wu, M. Jiang, A. Cao, L. Huang, X. Bo, Z. Xu, J. Org. Chem., 2023, 88, 17368-17380.

DOI: 10.1021/acs.joc.3c02195


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Abstract

A general, rapid, and scalable method for the preparation of α-halogenated ketones using N-alkenoxypyridinium salts as substrates and quaternary ammonium salts as halogen sources offers mild reaction conditions, excellent functional group tolerance, and a wide substrate scope.

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Key Words

α-chloroketones, α-bromoketones, α-iodoketones


ID: J42-Y2023