Sodium Carbonate-Promoted Formation of 5-Amino-1,2,4-thiadiazoles and 5-Amino-1,2,4-selenadiazoles with Elemental Sulfur and Selenium
Jun-Xu Lin, Guo-Hui Liu, Li-Qiu Liu, Ying-Chun Wang*, Yan He*
*Jishou University, Jishou 416000; Xuzhou University of Technology, Xuzhou 221018, People's
Republic of China, Email: wangyingchunjsu
163.com, hychemxzit.edu.cn
J.-X. Lin, G.-H. Liu, L.-Q. Liu, Y.-C. Wang, Y. He, J. Org. Chem., 2024, 89, 101-110.
DOI: 10.1021/acs.joc.3c01716
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Abstract
Sodium carbonate promotes a facile synthesis of 5-amino-1,2,4-thiadiazoles and 5-amino-1,2,4-selenadiazoles in good yields with elemental sulfur and selenium in the presence of air as the green oxidant. The reaction offers low cost, low toxicity, and stable sulfur and selenium sources, water as the sole byproduct, simple operation, and a broad substrate scope.
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proposed mechanism
Key Words
1,2,4-thiadiazoles, oxygen, multicomponent reactions
ID: J42-Y2024
