Chromium-Catalyzed Cross-Coupling of Methyl Ketones with Cyclic Ketones toward the Selective Synthesis of β-Branched β,γ-Unsaturated Ketones
Priyanka Adhikari, Nitumoni Hazarika, Kalishankar Bhattacharyya, Animesh Das*
*Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam, India,
Email: adas
iitg.ac.in
P. Adhikari, N. Hazarika, K. Bhattacharyya, A. Das, Org. Lett., 2024, 26, 286-291.
DOI: 10.1021/acs.orglett.3c03960
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Abstract
An aldol condensation of methyl ketones with cyclic ketones provides β-branched β,γ-unsaturated ketones in the presence of a chromium catalyst responsible for an isomerization. This highly chemoselective and regioselective reaction forms single-crossed condensation products even in reactions in which a mixture of products is possible.
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proposed mechanism for the isomerization
Key Words
cyclohexenes, aldol condensation
ID: J54-Y2024
