Ti(III)-Catalyzed Anti-Markovnikov Reduction of Epoxides with Borohydride

Guangchen Li, Jack R. Norton*

*Department of Chemistry, Columbia University, 3000 Broadway, New York, New York 10027, United States, Email: jrn11columbia.edu

G. Li, J. R. Norton, Org. Lett., 2024, 26, 1382-1386.

DOI: 10.1021/acs.orglett.3c04304

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Abstract

A readily available Ti catalyst carries out the anti-Markovnikov reduction of a wide range of epoxides under mild conditions in the presence of [BH₄]⁻ as both the electron and the hydrogen atom source.

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proposed mechanism

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Key Words

reduction of epoxides, lithium borohydride

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ID: J54-Y2024