Copper-Catalyzed Enantioconvergent Radical N-Alkylation of Diverse (Hetero)aromatic Amines
Xuan-Yi Du, Jia-Heng Fang, Ji-Jun Chen, Boming Shen, Wei-Long Liu, Jia-Yong Zhang, Xue-Man Ye, Ning-Yuan Yang, Qiang-Shuai Gu, Zhong-Liang Li*, Peiyuan Yu*, Xin-Yuan Liu*
*School of Physical Sciences, Great Bay University, Dongguan;
Southern University of Science and Technology, Shenzhen, China, Email: lizl
gbu.edu.cn,
yupysustech.edu.cn, liuxy3sustech.edu.cn
X.-Y. Du, J.-H. Fang, J.-J. Chen, B. Shen, W.-L. Liu, J.-Y. Zhang, X.-M. Ye, N.-Y. Yang, Q.-S. Gu, Z.-L. Li, P. Yu, X.-Y. Liu, J. Am. Chem. Soc., 2024, 146, 9444-9454.
DOI: 10.1021/jacs.4c02141
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Abstract
A general copper-catalyzed enantioconvergent radical N-alkylation of aromatic amines with secondary/tertiary alkyl halides deliver value-added chiral amines and exhibits catalyst-controlled stereoselectivity. This strategy accommodates diverse aromatic amines, especially bulky secondary and primary ones to (>110 examples).
see article for more examples
prosed catalytic cycle involving an outer-sphere nucleophilic
attack
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Key Words
ID: J48-Y2024
