Palladium-Catalyzed Formation of Aryl tert-Butyl Ethers from Unactivated Aryl Halides
Cynthia A. Parrish and Stephen L. Buchwald
*Department of Chemistry, Massachussets Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu
C. A. Parrish, S. L. Buchwald, J. Org. Chem, 2001, 66, 2498-2500.
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A palladium-catalyzed synthesis of aryl tert-butyl ethers from a variety of unactivated aryl bromides or chlorides is described. The ether products, which are precursors to phenols, are obtained in very good yield in the presence of air-stable dialkylphosphinobiphenyl ligands.
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