Palladium-Catalyzed Formation of Aryl tert-Butyl Ethers from Unactivated Aryl Halides
Cynthia A. Parrish and Stephen L. Buchwald
*Department of Chemistry, Massachussets Institute of Technology, Cambridge,
Massachusetts 02139, Email: sbuchwal
mit.edu
C. A. Parrish, S. L. Buchwald, J. Org. Chem., 2001, 66, 2498-2500.
DOI: 10.1021/jo001426z
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Abstract
A palladium-catalyzed synthesis of aryl tert-butyl ethers from a variety of unactivated aryl bromides or chlorides is described. The ether products, which are precursors to phenols, are obtained in very good yield in the presence of air-stable dialkylphosphinobiphenyl ligands.
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Key Words
Buchwald-Hartwig Reaction, tert-Butyl ethers, Phenols, Aryl ethers
ID: J42-Y2001-550
