Copper-Catalyzed Domino Halide Exchange-Cyanation of Aryl Bromides
Jacopo Zanon, Artis Klapars and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge,
Massachusetts 02139, Email: sbuchwal
mit.edu
J. Zanon, A. Klapars, S. L. Buchwald, J. Am. Chem. Soc., 2003, 125, 2890-2891.
DOI: 10.1021/ja0299708
Abstract
An efficient, mild, and inexpensive copper-catalyzed domino halogen exchange-cyanation procedure for aryl bromides was developed. The new method represents a significant improvement over the traditional Rosenmund-von Braun reaction: the use of catalytic amounts of copper and an apolar solvent greatly simplifies the isolation and purification. In addition, the new method exhibits excellent functional group compatibility.
Key Words
Cyanations, Rosenmund-von Braun Reaction
ID: J48-Y2002-1260
