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Highly Enantioselective Desymmetrization of Anhydrides by Carbon Nucleophiles: Reaction of Grignard Reagents in the Presence of (-)-Sparteine

Ryo Shintani, Gregory C. Fu*

*Departement of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA), Email:

R. Shintani, G. C. Fu, Angew. Chem. Int. Ed., 2002, 41, 1057-1059.

DOI: 10.1002/1521-3773(20020315)41:6<1057::AID-ANIE1057>3.0.CO;2-H

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The first enantioselective desymmetrizations of anhydrides with carbon-based nucleophiles by employing (-)-sparteine as a chiral ligand are described. These C-C bond-forming reactions proceed in good enantioselectivity for a range of anhydrides.

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Key Words

Grignard Reaction, Acylation

ID: J06-Y2002-960