Highly Enantioselective Desymmetrization of Anhydrides by Carbon Nucleophiles: Reaction of Grignard Reagents in the Presence of (-)-Sparteine
Ryo Shintani, Gregory C. Fu*
*Departement of Chemistry, Massachusetts Institute of Technology, Cambridge,
MA 02139 (USA), Email: gcf
mit.edu
R. Shintani, G. C. Fu, Angew. Chem. Int. Ed., 2002, 41, 1057-1059.
DOI: 10.1002/1521-3773(20020315)41:6<1057::AID-ANIE1057>3.0.CO;2-H
see article for more reactions
Abstract
The first enantioselective desymmetrizations of anhydrides with carbon-based nucleophiles by employing (-)-sparteine as a chiral ligand are described. These C-C bond-forming reactions proceed in good enantioselectivity for a range of anhydrides.
see article for more examples
Key Words
ID: J06-Y2002-960
