(Cyanomethyl)trialkylphosphonium Iodides: Efficient Reagents for the Intermolecular Alkylation of Amines with Alkohols in Solution and on Solid Phase
Florencio Zaragoza* and Henrik Stephensen
*Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Malov (Denmark), Email: flonovonordisk.com
F. Zaragoza, H. Stephensen, J. Org. Chem, 2001, 66, 2518-2521.
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(Cyanomethyl)phosphonium iodides are easy to prepare and to handle. These reagents efficiently promote the direct, intermolecular N-alkylation of amines with alcohols.
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