Use of Sonication for the Coupling of Sterically Hindered Substrates in the Phenolic Mitsunobu Reaction
Salvatore D. Lepore* and Yuanjun He
*Department of Chemistry, Florida Atlantic University, Boca Raton, Florida
33431-0991, Email: slepore
fau.edu
S. D. Lepore, Y. He, J. Org. Chem., 2003, 68, 8261-8263.
DOI: 10.1021/jo0345751
Abstract
A vast rate increase has been achieved by the use of high concentration combined with sonication in the Mitsunobu reaction of phenols with alcohols where at least one substrate is sterically demanding.
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Key Words
Mitsunobu Reaction, Aryl Ethers, Bulky Aryl Ethers, Sonochemistry, Sonication, Phenolic Mitsunobu Reaction, Rate Enhancement
ID: J42-Y2003-900
