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Use of Sonication for the Coupling of Sterically Hindered Substrates in the Phenolic Mitsunobu Reaction

Salvatore D. Lepore* and Yuanjun He

*Department of Chemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991, Email:

S. D. Lepore, Y. He, J. Org. Chem., 2003, 68, 8261-8263.

DOI: 10.1021/jo0345751


A vast rate increase has been achieved by the use of high concentration combined with sonication in the Mitsunobu reaction of phenols with alcohols where at least one substrate is sterically demanding.

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Key Words

Mitsunobu Reaction, Aryl Ethers, Bulky Aryl Ethers, Sonochemistry, Sonication, Phenolic Mitsunobu Reaction, Rate Enhancement

ID: J42-Y2003-900