Organic Chemistry Portal



Zinc tetrafluoroborate catalyzed Mannich-type reaction of aldimines and silyl enol ethers in aqueous medium

Brindaban C. Ranu*, Sampak Samanta and Sankar K. Guchhait

*Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Calcutta 700 032, India, Email:

B. C. Ranu, S. Samanta, S. K. Guchhait, Tetrahedron, 2002, 58, 983-988.

DOI: 10.1016/S0040-4020(01)01177-2


The use of zinc tetrafluoroborate as a catalyst in Mannich-type addition of silyl enol ethers to aldimines in aqueous THF provides β-amino ketones or β-amino esters in high yields. A one-pot reaction of an aldehyde, amine and silyl enolate also works well.

see article for more reactions

Key Words

Mannich reaction, β-Amino Ketones

ID: J72-Y2002-1010