Zinc tetrafluoroborate catalyzed Mannich-type reaction of aldimines and silyl enol ethers in aqueous medium
Brindaban C. Ranu*, Sampak Samanta and Sankar K. Guchhait
*Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Calcutta 700 032, India, Email: ocbrmahendra.iacs.res.in
B. C. Ranu, S. Samanta, S. K. Guchhait, Tetrahedron, 2002, 58, 983-988.
The use of zinc tetrafluoroborate as a catalyst in Mannich-type addition of silyl enol ethers to aldimines in aqueous THF provides β-amino ketones or β-amino esters in high yields. A one-pot reaction of an aldehyde, amine and silyl enolate also works well.
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