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Copper-Catalyzed Coupling of Alkylamines and Aryl Iodides: An Efficient System Even in an Air Atmosphere

Fuk Yee Kwong, Artis Klapars and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

F. Y. Kwong, A. Klapars, S. L. Buchwald, Org. Lett., 2002, 4, 581-584.

DOI: 10.1021/ol0171867(free Supporting Information)

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A simple, mild, and versatile protocol for the amination of aryl iodides uses CuI as the catalyst and ethylene glycol as ligand in 2-propanol. This procedure is relatively insensitive to moisture and can be performed under an air atmosphere with comparable yield.

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Key Words

Ullmann Reaction, Amination

ID: J54-Y2002-040