A Novel Synthesis of 2-Aminopyrroles Using a Three-Component Reaction
Vijay Nair*, A. U. Vinod and C. Rajesh
*Organic Chemistry Division, Regional Research Laboratory, CSIR, Trivandrum 695 019, India, Email: gvncsrrltrd.ren.nic.in
V. Nair, A. U. Vinod, C. Rajesh, J. Org. Chem., 2001, 66, 4427-4429.
DOI: 10.1021/jo001714v (free Supporting Information)
A novel and efficient multicomponent reaction of N-tosylimines, DMAD, and isocyanides for the synthesis of 2-aminopyrrole systems was uncovered. The mechanism, which involves a 1,3-dipolar cycloaddition, is discussed.
see article for more examples
V. Nair, A. R. Sreekanth, N. Abhilash, A. T. Biju, B. R. Devi, R. S. Menon, N. P. Rath, R. Srinivas, Synthesis, 2003, 1895-1902.