Organic Chemistry Portal



The First Asymmetric Intramolecular Stetter Reaction

Dieter Enders*, Klaus Breuer and Jan Runsink

*Institut für Organische Chemie der Technischen Hochschule, Landoltweg 1, D-52074 Aachen, Email:

D. Enders, K. Breuer, J. Runsink, Helv. Chim. Acta, 1996, 79, 1899-1902.

DOI: 10.1002/hlca.19960790712


The first enantioselective intramolecular catalytic Stetter reaction, which opens up a short and efficient pathway to enantiomerically enriched chroman-4-ones, is reported.

see article for more examples

model explaining the facial selectivity

Key Words

Stetter 1,4-Dicarbonyl Synthesis, Organocatalysis, Chromanones

ID: J30-Y1996-020