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Palladium-Catalyzed Synthesis of Aryl Ketones from Boronic Acids and Carboxylic Acids Activated in situ by Pivalic Anhydride

Lukas J. Goossen* and Keya Ghosh

*Institut für Chemie - Organische Chemie, TU Kaiserslautern, Erwin-Schrödinger-Straße, Geb. 54, 67663 Kaiserslautern Email: goossenchemie.uni-kl.de

L. J. Goossen, K. Ghosh, Eur. J. Org. Chem., 2002, 3254-3267.

DOI: 10.1002/1099-0690(200210)2002:19<3254::AID-EJOC3254>3.0.CO;2-6


Abstract

A new palladium-catalyzed cross-coupling reaction between arylboronic acids and mixed anhydrides, generated in situ from carboxylic acids and pivalic anhydride, in wet THF at 60°C is presented.

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proposed mechanism (simplified)



Key Words

Aryl Ketones, Arylboronic Acids, Carboxylic Acids, Catalysis, Palladium


ID: J24-Y2002-020