Enantioselective Direct-Addition of Terminal Alkynes to Imines Catalyzed by Copper(I)pybox Complex in Water and in Toluene
Chunmei Wei and Chao-Jun Li*
*Department of Chemistry, McGill University, Montreal, Quebec, H3A2K6,
Canada, Email: cj.li
mcgill.ca
C. Wei, C.-J. Li, J. Am. Chem. Soc., 2002, 124, 5638-5639.
DOI: 10.1021/ja026007t
Abstract
Highly enantioselective direct alkyne-imine additions catalyzed by Cu(I)OTf and Evan's pybox ligands were developed in water and in toluene. The process is simple and allows the synthesis of various propargylic amines in high ees and good yields.
see article for more examples
Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines
C. Wei, J. T. Mague, C.-J. Li, PNAS, 2004, 101, 5749-5754.
DOI: 10.1073/pnas.0307150101
Key Words
ID: J48-Y2002-1120
