The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes
Alan B. Northrup and David W. C. MacMillan*
*Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, Email: dmacmillcaltech.edu
A. B. Northtrup, D. W. C. MacMillan, J. Am. Chem. Soc., 2002, 124, 6798-6799.
DOI: 10.1021/ja0262378 (free Supporting Information)
An efficient enantioselective catalytic direct cross-aldol reaction of aldehydes has been accomplished using proline as catalyst. Structural variation in both the aldol donor and aldol acceptor allows facile enantioselective access to a broad range of β-hydroxy aldehydes.
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