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The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes

Alan B. Northrup and David W. C. MacMillan*

*Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, Email:

A. B. Northtrup, D. W. C. MacMillan, J. Am. Chem. Soc., 2002, 124, 6798-6799.

DOI: 10.1021/ja0262378 (free Supporting Information)


An efficient enantioselective catalytic direct cross-aldol reaction of aldehydes has been accomplished using proline as catalyst. Structural variation in both the aldol donor and aldol acceptor allows facile enantioselective access to a broad range of β-hydroxy aldehydes.

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Key Words

Organocatalysis, Aldol Addition

ID: J48-Y2002-1170