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Ruthenium-Catalyzed S-Propargylation of Thiols Enables the Rapid Synthesis of Propargylic Sulfides

Teruyuki Kondo, Yusuke Kanda, Atsushi Baba, Kenji Fukuda, Ayako Nakamura, Kenji Wada, Yasuhiro Morisaki, and Take-aki Mitsudo*

*Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan, Email: mitsudoscl.kyoto-u.ac.jp

T. Kondo, Y. Kanda, A. Baba, K. Fukuda, A. Nakamura, K. Wada, Y. Morisaki, T.-A. Mitsudo, J. Am. Chem. Soc., 2002, 124, 12960-12961.

DOI: 10.1021/ja027750o


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Abstract

A ruthenium-catalyzed S-propargylation of thiols by propargylic carbonates under neutral conditions, in which specific requirements inherent to the different reactivities of aliphatic and aromatic thiols was achieved by tuning both the nature of the ligands and the experimental conditions.

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Key Words

Propargylic sulfides


ID: J48-Y2002-1330