Suzuki-Miyaura Cross-Coupling Reactions of Potassium Alkenyltrifluoroborates
Gary A. Molander* and Carmen R. Bernardi
*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, Email: gmolandrsas.upenn.edu
G. A. Molander, C. R. Bernardi, J. Org. Chem., 2002, 67, 8424-8429.
DOI: 10.1021/jo026236y (free Supporting Information)
The palladium-catalyzed cross-coupling reaction of potassium alkenyltrifluoroborates with aryl and heteroaryl halides and triflates proceeds readily with moderate to excellent yields. The alkenyl cross-coupling reaction can generally be effected using 2 mol % of PdCl2(dppf)ĚCH2Cl2 as catalyst in i-PrOH-H2O in the presence of t-BuNH2 as the base.
see article for more examples
G. A. Molander, T. Fumagalli, J. Org. Chem., 2006, 71, 5743-5747.
G. A. Molander, A. R. Brown, J. Org. Chem., 2006, 71, 9681-9686.