Highly Enantioselective Phenylacetylene Additions to Both Aliphatic and Aromatic Aldehydes
Ge Gao, David Moore, Ru-Gang Xie and Lin Pu*
*Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, Email: lp6nvirginia.edu
G. Gao, D. Moore, R.-G. Xie, L. Pu, Org. Lett., 2002, 4, 4143-4146.
DOI: 10.1021/ol026921r (free Supporting Information)
Inexpensive BINOL in combination with Ti(OiPr)4 catalyzes the reaction of alkynylzinc reagents with a broad range of aldehydes to generate chiral propargyl alcohols with high enantioselectivity at room temperature.
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