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Highly Enantioselective Phenylacetylene Additions to Both Aliphatic and Aromatic Aldehydes

Ge Gao, David Moore, Ru-Gang Xie and Lin Pu*

*Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, Email: 

G. Gao, D. Moore, R.-G. Xie, L. Pu, Org. Lett., 2002, 4, 4143-4146.

DOI: 10.1021/ol026921r (free Supporting Information)


Inexpensive BINOL in combination with Ti(OiPr)4 catalyzes the reaction of alkynylzinc reagents with a broad range of aldehydes to generate chiral propargyl alcohols with high enantioselectivity at room temperature.

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Key Words

Propargylic alcohols, Addition

ID: J54-Y2002-300