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Direct Asymmetric Aldol Reactions of Acetone Using Bimetallic Zinc Catalysts

Barry M. Trost*, Elliad R. Silcoff and Hisanaka Ito

*Department of Chemistry, Stanford University, Stanford, California 94305-5080, Email:

B. M. Trost, E. R. Silcoff, H. Ito, Org. Lett., 2001, 3, 2497-2500.

DOI: 10.1021/ol0161211 (free Supporting Information)

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The enantioselective aldol reaction of acetone with several aldehydes using a novel binuclear zinc catalyst gave products in good yields and with a high level of enantioselectivity.

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proposed catalytic cycle of the asymmetric Aldol Reaction

Key Words

Aldol Addition

ID: J54-Y2001-090