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Iron-Catalyzed Cross-Coupling Reactions

Alois Fürstner,* Andreas Leitner, María Méndez and Helga Krause

*Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim/Ruhr, Germany, Email: fuerstnermpi-muelheim.mpg.de

A. Fuerstner, A. Leitner, M. Méndez, H. Krause, J. Am. Chem. Soc., 2002, 124, 13856-13863.

DOI: 10.1021/ja027190t


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Abstract

Simple, cheap, and toxicologically benign iron salts turned out to be highly efficient precatalysts for cross-coupling reactions of alkyl or aryl Grignard reagents, zincates, or organomanganese species with aryl and heteroaryl chlorides, triflates, and even tosylates. Aryl bromides and iodides are prone to a reduction of their C-X bonds in the presence of the iron catalyst. The exceptionally mild reaction conditions tolerate a series of functional groups such as esters, ethers, nitriles, sulfonates, sulfonamides, thioethers, acetals, alkynes, and -CF3 groups.

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Key Words

Substituted Arenes, Grignard Reagents, Iron Catalysis


ID: J48-Y2002-1370