Palladium-Catalyzed Coupling of Alkyl Chlorides and Grignard Reagents
Anja C. Frisch, Nadim Shaikh, Alexander Zapf and Matthias Beller*
*Institut für Organische Katalyseforschung an der Universität Rostock e.V.,
Buchbinderstrasse 5-6, 18055 Rostock (Deutschland), Email:
matthias.beller
ifok.uni-rostock.de
A. C. Frisch, N. Shaikh, A. Zapf, M. Beller, Angew. Chem. Int. Ed., 2002, 41, 4056-4059.
DOI: 10.1002/1521-3773(20021104)41:21<4056::AID-ANIE4056>3.0.CO;2-8
Abstract
A novel method for the palladium-catalyzed cross-coupling of alkyl chlorides and Grignard reagents has been developed. Good to excellent yields of the coupling products were obtained at room temperature, and functional groups such as ethers, esters, acetals, fluorides, nitriles, aryl and benzyl were tolerated.
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Key Words
alkyl chlorides, cross-coupling, Grignard reaction, Kumada coupling, palladium, alkyl arenes
ID: J06-Y2002-310
