Palladium-Catalyzed Intramolecular Oxidative Alkylation of Unactivated Olefins

Tao Pei, Xiang Wang and Ross A. Widenhoefer*

*Duke University, P. M. Gross Chemical Laboratory, Durham, North Carolina 27708-0346, Email: rwidenhochem.duke.edu

T. Pei, X. Wang, R. A. Widenhoefer, J. Am. Chem. Soc., 2003, 125, 648-649.

DOI: 10.1021/ja026317b

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Abstract

A mild, palladium-catalyzed intramolecular oxidative alkylation of various ζ-alkenyl β-diketones and ζ-alkenyl β-keto esters in the presence of CuCl₂ at room temperature formed the corresponding 2-cyclohexenones in high yield.

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Key Words

Cyclization, Active Methylenes

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ID: J48-Y2003-1300