Copper(I) Hydride-Catalyzed Asymmetric Hydrosilylation of Heteroaromatic Ketones
Bruce H. Lipshutz*, Asher Lower and Kevin Noson
*Department of Chemistry and Biochemistry, University of California - Santa
Barbara, Santa Barbara, California 93106, Email: lipshutzchem.ucsb.edu
B. H. Lipshutz, A. Lower, K. Noson, Org. Lett., 2002, 4, 4045-4048.
DOI: 10.1021/ol026755n
Abstract
A complex of CuH and Takasago's nonracemic ligand, DTBM-SEGPHOS, is an especially reactive reagent for the asymmetric hydrosilylation of heteroaromatic ketones under very mild conditions. PMHS serves as an inexpensive source of hydride for the in situ generation of CuH.
see article for more examples
B. H. Lipshutz, C. C. Caires, P. Kuipers, W. Chrisman, Org. Lett., 2003, 5, 3085-3088.
Nonracemic Diarylmethanols From CuH-Catalyzed Hydrosilylation of Diaryl Ketones
C.-T. Lee, B. H. Lipshutz, Org. Lett., 2008, 10, 4187-4190.
Key Words
Hydrosilylation, PMHS, CuH, Reduction
ID: J54-Y2002-350