Microwave Assisted Synthesis of 1,5-Disubstituted Hydantoins and Thiohydantoins in Solvent-Free Conditions
Satya Paul*, Mukta Gupta, Rajive Gupta, André Loupy
*Department of Chemistry, University of Jammu, Jammu-180 006, India, Email: paul7rediffmail.com
S. Paul, M. Gupta, R. Gupta, A. Loupy, Synthesis, 2002, 75-78.
1,5-Disubstituted hydantoins/thiohydantoins have been synthesized in good yield by a microwave-promoted solvent-free condensation of arylglyoxals and phenylurea/thiourea using polyphosphoric ester (PPE) as a reaction mediator. The workup is simple and involves treatment with ice-cold water.
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