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Microwave Assisted Synthesis of 1,5-Disubstituted Hydantoins and Thiohydantoins in Solvent-Free Conditions

Satya Paul*, Mukta Gupta, Rajive Gupta, André Loupy

*Department of Chemistry, University of Jammu, Jammu-180 006, India, Email:

S. Paul, M. Gupta, R. Gupta, A. Loupy, Synthesis, 2002, 75-78.

DOI: 10.1055/s-2002-19308


1,5-Disubstituted hydantoins/thiohydantoins have been synthesized in good yield by a microwave-promoted solvent-free condensation of arylglyoxals and phenylurea/thiourea using polyphosphoric ester (PPE) as a reaction mediator. The workup is simple and involves treatment with ice-cold water.

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Key Words

arylglyoxals, solvent-free conditions, polyphosphoric ester (PPE), microwave activation, hydantoins

ID: J66-Y2002-1400