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Microwave-Accelerated Solvent-Free Synthesis of Thioketones, Thiolactones, Thioamides, Thionoesters, and Thioflavonoids

Rajender S. Varma* and Dalip Kumar

*Sustainable Technology Division, National Risk Management Research Laboratory, U.S. Environmental Protection Agency, 26 West Martin Luther King Drive, MS 443, Cincinnati, Ohio 45268, Email:

R. S. Varma, D. Kumar, Org. Lett., 1999, 1, 697-700.

DOI: 10.1021/ol990629a


An expeditious, solvent-free, and high yield conversion of ketones, flavones, isoflavones, lactones, amides, and esters to the corresponding thio analogues is described utilizing Lawesson's reagent in a process that circumvents the use of dry solvents and excess of the reagent.

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Key Words

Lawesson's Reagent, Thioketones, Thioamides, Thionoesters Microwave Synthesis

ID: J54-Y1999-400