Catalytic Meerwein-Ponndorf-Verley (MPV) and Oppenauer (OPP) Reactions: Remarkable Acceleration of the Hydride Transfer by Powerful Bidentate Aluminum Alkoxides
Takashi Ooi, Tomoya Miura, Yoshifumi Itagaki, Hayato Ichikawa, Keiji Maruoka*
*Department of Chemistry, Graduate School of Science, Kyoto University,
Sakyo, Kyoto 606-8502, Japan, Email: maruoka
kuchem.kyoto-u.ac.jp
T. Ooi, T. Miura, Y. Itagaki, H. Ichikawa, K. Maruoka, Synthesis, 2002, 279-291.
DOI: 10.1055/s-2002-19802
Abstract
Bidentate aluminium alkoxides are highly efficient catalysts for the Meerwein-Ponndorf-Verley (MPV) reduction and the Oppenauer (OPP) oxidation in a truly catalytic manner offering highly chemoselective hydride transfer from a secondary alcohol moiety to the remote carbonyl group. The catalytic system is also applicable to high-speed, catalytic Tishchenko reactions.
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Key Words
Meerwein-Ponndorf-Verley (MPV) reduction, Oppenauer (OPP) oxidation, bidentate aluminum alkoxides, carbonyl compounds, Tishchenko reaction, alcohols
ID: J66-Y2002-1420
