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The First Suzuki Cross-Couplings of Aryltrimethylammonium Salts

Simon B. Blakey and David W. C. MacMillan*

*Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, Email: dmacmillcaltech.edu

S. B. Blakey, D. W. C. MacMillan, J. Am. Chem. Soc., 2003, 125, 6046-6047.

DOI: 10.1021/ja034908b (free Supporting Information)


Abstract

A suzuki cross-coupling reaction of aryltrimethylammonium triflates based on an IMes·Ni(0) catalyst system tolerates a wide range of electron-withdrawing and electron-donating substituents on both coupling partners. This methodology constitutes a novel, mild method to activate anilines for metal-catalyzed cross-coupling reactions.


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Key Words

Suzuki Coupling, Biaryls


ID: J48-Y2003-1490