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One-pot Conversion of t-Butyl Carbamates to Amides with Acyl Halide-Methanol Mixtures

Abdesslame Nazih*, Denis Heissler

*Université Louis Pasteur et Centre National de la Recherche Scientifique, Institut de Chimie, BP 296, 67008 Strasbourg, France, Email:

A. Nazih, D. Heissler, Synthesis, 2002, 203-206.

DOI: 10.1055/s-2002-19803


Acyl halide-methanol mixtures are efficient reagents for the one-pot transformation of t-butyl carbamates into amides. This transformation can be carried out in the presence of a benzyloxycarbonyl group.

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Key Words

tert-butyl carbamates, acylations, amides, chemoselectivity, protecting groups

ID: J66-Y2002-1450